Fredag 14 november 2014, Claudio Altafini, ISY, Linköpings universitet
Talare: Professor Claudio Altafini, ISY, Linköpings universitet
Claudio Altafini obtained a Laurea degree in Electrical Engineering from the University of Padova, Italy, in 1996 and a PhD in Optimization and Systems Theory from KTH in 2001. From 2001 till 2013 he was with SISSA (Int. School for Advanced Studies) in Trieste, Italy. Since 2014 he is a professor in Automatic Control at ISY, Linkoping University. His research interest are in the area of nonlinear control, complex networks and systems biology.
Titel: Modeling metabolic networks: constraint-based models and optimization problems
Tid och plats: Fredag 14 november 2014, Hopningspunkten, 10:15-11:15
Sammanfattning: In this talk I will give an overview of the commonly used "Flux Balance Analysis" framework for modeling genome-wide metabolic networks and discuss some of its standard uses, like the computation of the growth rate as a linear programming problem, or the minimization of the metabolic adjustment that follows a gene knockout as a quadratic programming problem. I will then present the results of our research on describing the effect of drugs and of drug combinatorics on a metabolic network as a bilevel optimization problem.
Senast uppdaterad: 2014-10-29