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Highly Water-Dispersible Surface-Modified Gd2O3 Nanoparticles for Potential Dual-Modal Bioimaging

Zhangjun Hu,  Maria Ahrén,  Linnéa Selegård,  Caroline Skoglund, Fredrik Söderlind,  Maria Engström, Xuanjun Zhang,  Kajsa Uvdal*

Chemistry - A European Journal, 2013, 19, 12658–12667.

 

Bioimaging

Water-dispersible and luminescent gadolinium oxide (GO) nanoparticles (NPs) were obtained cleverly by using fluorescent small water-soluble conjugated carboxylates (HL) coating. The obtained GO NPs (GO-L) show long-term colloidal stability and intense blue fluorescence. The optical characteristic of particles was further promoted by doping europium(III) component. The europium(III) doped GO-L (Eu:GO-L) gives intense sensitized red luminescence of europium(III) through an antenna effect (the conjugated carboxylates absorb the energy from incident light and then transfer it to europium(III) center). The size of the particles was well controlled and by that promising for biomedical application. The average diameter of the GO core in GO-L is about 4 nm, and the hydrodynamic diameters of the monodispersed GO-in estimated to be ~13 nm. Importantly, effective longitudinal water proton relaxivities of these nanoparticles are higher than those of positive contrast agents based on gadolinium complexes such as Gd-DOTA, which are currently used clinically for clinical magnetic resonance imaging (MRI). In this work, the particles have also been successfully tested in cellular imaging for dual modalities (photoluminescent imaging and magnetic resonance imaging).


Thu Dec 19 13:58:34 CET 2013




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Last updated: Thu Dec 19 14:15:58 CET 2013